Researchers funded by the National Institutes of Health have discovered a gene that could serve as a target for a new, non-hormonal contraceptive. The gene, arrestin domain containing 5 (ARRDC5) is present in several mammalian species and controls the last step in sperm maturation. Deactivating the gene results in lower sperm count and sperm with impaired movement that are incapable of fertilizing an egg—without any apparent ill effects elsewhere in the body.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Director's Corner: Supporting Small Business Innovations
Small businesses play a critical role in driving scientific progress by helping to move innovations out of labs and into the public marketplace. NICHD grants to small businesses have supported development of products ranging from the first FDA-approved endometriosis treatment to at-home rehabilitation devices.
Release: “Eat, Sleep, Console” reduces hospital stay and need for medication among opioid-exposed infants
Researchers have found the “Eat, Sleep, Console” (ESC) care approach to be more effective than using the Finnegan Neonatal Abstinence Scoring Tool (FNAST) to assess and manage opioid-exposed newborns, according to a national clinical trial funded by the National Institutes of Health.
Media Advisory: Biomarker pattern found in kids with COVID 19-linked inflammatory syndrome
Children with multisystem inflammatory syndrome (MIS-C)—a rare condition linked with the virus that causes COVID-19—have biochemical indicators of cell injury and cell death that are distinct from other children with COVID-19, according to a study funded by the National Institutes of Health.
Science Update: Urea in breast milk feeds beneficial bacteria in infant gut, NIH-funded study suggests
Urea, present in breast milk but not digested by the infant, appears to foster the growth of beneficial bacteria in the infant gut, suggests a study funded by the National Institutes of Health. Urea is a nitrogen-containing waste product of protein digestion. In return for the breast milk-supplied urea, the bacteria provide the infant with essential nutrients. The results have important implications for the development of infant formula.
Science Update: Children born to women with COVID-19 could be at risk for heart disease, diabetes in later life, NIH-funded study suggests
Infants born in 2020 through mid-2021 to women with COVID-19 weighed less at birth, but grew at a faster rate than a comparable group born to women who did not have COVID-19, according to a study funded by the National Institutes of Health. Previous studies have found that preterm infants and other infants who are small or underweight at birth and who undergo catch-up growth in the first year are at higher risk for later life obesity, heart disease, high blood pressure and diabetes, compared to infants born at normal weight. The authors called for additional studies of infants whose mothers had COVID-19 during pregnancy to learn if they have increased health risks later in life.
Release: Tranexamic acid does not appear to prevent maternal hemorrhage after cesarean delivery
Tranexamic acid appears no more effective than placebo in reducing the need for blood transfusion or preventing maternal death in patients with increased risk for excessive bleeding because of cesarean delivery, according to a study funded by the National Institutes of Health. Tranexamic acid slows the natural breakdown of blood clots and was considered promising for reducing the risk of excessive bleeding after giving birth—known as postpartum hemorrhage—after cesarean delivery.
Item of Interest: NICHD announces awards for Maternal-Fetal Medicine Units Network
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has announced new funding for participating centers in its Maternal-Fetal Medicine Units (MFMU) Network.
Director's Corner: Addressing Inequities to IMPROVE Maternal Health for All
Black people are about three times as likely as White people to die from a pregnancy-related cause, regardless of income or education level. The NIH-wide IMPROVE initiative works to reduce preventable pregnancy-related deaths and complications and promote health equity.
Science Update: Women report small, temporary increase in menstrual flow after COVID-19 vaccination, NIH-funded study suggests
Compared to unvaccinated women, women vaccinated for COVID-19 have a slightly higher risk of a heavier period after vaccination, suggests a study funded by the National Institutes of Health. However, flow returns to normal in the next menstrual period.
Item of Interest: NICHD announces awards for Neonatal Research Network
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has announced new funding for participating centers in its Neonatal Research Network (NRN). The purpose of the NRN is to improve healthcare and outcomes for newborns.
Science Update: Placental cells secrete tiny structures that may play a role in regulating blood sugar during pregnancy, NIH-funded study suggests
Placental cells secrete extracellular vesicles—tiny, balloon-like structures containing proteins, enzymes, DNA, and other molecules capable of transmitting chemical messages between cells—that appear to help regulate glucose uptake by maternal cells, according to a mouse study funded by the National Institutes of Health. In a series of experiments, the researchers found evidence that release of the vesicles follows placental release of the enzyme O-glycosyl transferase (OGT) after glucose levels rise. The findings may inform the development of new treatments for gestational (pregnancy-related) diabetes.
Item of Interest: NIH selects next round of winners in the RADx® Tech for Maternal Health Challenge
The National Institutes of Health announced the next round of winners of its RADx® Tech for Maternal Health Challenge—an $8 million prize competition to accelerate development of technologies to improve maternal health outcomes.
Science Update: Symptoms of MIS-C lessened during the pandemic, but still serious, NIH-funded study suggests
Serious complications from a rare childhood condition linked to COVID-19 infection appear to have decreased as SARS-CoV-2 evolved from 2020 to 2022, suggests a study funded by the National Institutes of Health. The condition, called multisystem inflammatory syndrome in children (MIS-C), inflames different body parts, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. The authors noted, however, that while the proportion of those with severe complications has dropped, 37% of children hospitalized with MIS-C needed intensive care.
Science Update: Risk of developmental delays may be higher for HIV-free children whose mothers began antiretroviral treatment during pregnancy, NIH-funded study suggests
HIV-free children whose mothers started taking anti-HIV medications while they were in the womb may be at higher risk for lower-than-average scores in one or more areas of development at age 5, according to a study supported by the National Institutes of Health.
Director's Corner: Fostering Inclusion in Down Syndrome Research
The theme for this year’s World Down Syndrome Day—With us, not for us—reflects a major goal of NIH’s INCLUDE project, which NICHD co-leads. INCLUDE aims to increase the participation of people with Down syndrome and their families in clinical research to expand our knowledge about the condition and its links to other health issues, with the ultimate goal of improving the health and quality of life of affected individuals.
Release: New, non-invasive imaging tool maps uterine contractions during labor
The tool has the potential to assist with preterm birth, labor management and clinical decisionmaking.
Science Update: Uterine fibroids may slightly increase fetal size but not enough to interfere with birth process, NIH study suggests
Uterine fibroids during pregnancy do not appear to result in undersized newborns, suggests a study by researchers at the National Institutes of Health. The finding allays concerns from previous studies that fibroids might result in smaller-than-normal infants. In fact, the study found that infants born to mothers with fibroids had slightly larger head, arm and thigh circumferences, though not to the extent that they would interfere with birth. The researchers also confirmed prior results suggesting a link between fibroids and increased risk for preterm birth.
Media Advisory: Researchers identify compounds that could lead to an on-demand, short-term contraceptive for men
In a mouse study, researchers funded by the National Institutes of Health have identified a potential non-hormonal contraceptive that men could take shortly before sexual activity and have fertility restored the next day. Researchers gave male mice a compound that temporarily disables soluble adenylyl cyclase, the enzyme essential for activating a sperm cell’s ability to swim and mature so that it can travel through the female reproductive tract and fertilize an egg.
Science Update: Infants’ cries may predict later developmental problems, NIH-funded study suggests
Characteristics of the cries of preterm infants may help predict their risk for long-term developmental and behavioral problems, suggests an NICHD-funded study. The findings may lead to tools to identify babies at highest risk for such issues, aiding early treatment or prevention efforts.